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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9045423 B1

PDFFull Text
Date of Patent:
Jun. 02, 2015

Filed:

May. 12, 2014

Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient

Applicant:

Kowa Company, Ltd., Nagoya-shi, Aichi, JP;

Inventors:

Masanori Ashikawa, Higashimurayama, JP;

Junya Tagashira, Higashimurayama, JP;

Akiyasu Koketsu, Higashimurayama, JP;

Toshiharu Morimoto, Higashimurayama, JP;

Takahiro Kitamura, Fuji, JP;

Syunji Takemura, Higashimurayama, JP;

Gen Watanabe, Higashimurayama, JP;

Tatsuaki Nishiyama, Higashimurayama, JP;

Satoshi Goda, Higashimurayama, JP;

Masaki Yamabi, Higashimurayama, JP;

Takeshi Doi, Higashimurayama, JP;

Hiroyuki Ishiwata, Higashimurayama, JP;

Assignee:

KOWA COMPANY, LTD., Nagoya-shi, JP;

Attorney:

Westerman, Hattori, Daniels & Adrian, LLP

Primary Examiner:

Wu-Cheng Winston Shen

Assistant Examiner:

Jean Cornet

Int. Cl.
CPC ...
A01N 57/26 (2006.01); A61K 31/675 (2006.01); C07D 215/42 (2006.01); A61K 31/47 (2006.01); A61K 31/4706 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/69 (2006.01); C07D 215/233 (2006.01); C07D 215/44 (2006.01); C07D 215/46 (2006.01); C07D 215/48 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 215/42 (2013.01); A61K 31/47 (2013.01); A61K 31/4706 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/69 (2013.01); C07D 215/233 (2013.01); C07D 215/44 (2013.01); C07D 215/46 (2013.01); C07D 215/48 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 405/12 (2013.01);
Abstract

Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R, R, R, Rand Rindependently represent a hydrogen atom, a Calkyl group, or the like; R, R, R, R, R, Rand Rindependently represent a hydrogen atom, a halogen atom, a Calkyl group, or the like; A represents N—R, a sulfur atom, or an oxygen atom; Rrepresents a hydrogen atom, a Calkyl group, or the like; B represents a Caryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

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