The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 02, 2015

Filed:

Aug. 14, 2009
Applicants:

Bette T. Korber, Los Alamos, NM (US);

William Fischer, Sante Fe, NM (US);

Norman Letvin, Boston, MA (US);

Hua-xin Liao, Durham, NC (US);

Barton F. Haynes, Durham, NC (US);

Beatrice H. Hahn, Birmingham, AL (US);

Inventors:

Bette T. Korber, Los Alamos, NM (US);

William Fischer, Sante Fe, NM (US);

Norman Letvin, Boston, MA (US);

Hua-Xin Liao, Durham, NC (US);

Barton F. Haynes, Durham, NC (US);

Beatrice H. Hahn, Birmingham, AL (US);

Assignees:

LOS ALAMOS NATIONAL SECURITY, LLC, Los Alamos, NM (US);

BETH ISRAEL DEACONESS MEDICAL CENTER, Boston, MA (US);

DUKE UNIERSITY, Durham, NC (US);

THE UAB RESEARCH FOUNDATION, Birmingham, AL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/21 (2006.01); C07K 14/005 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/21 (2013.01); A61K 2039/53 (2013.01); C07K 14/005 (2013.01); C12N 2710/24143 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16134 (2013.01);
Abstract

The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine containing nucleic acids encoding HIV-1 gag mosaic proteins, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.


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