The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2015
Filed:
Jun. 15, 2004
Barrett Rabinow, Skokie, IL (US);
James E. Kipp, Wauconda, IL (US);
Howard Gendelman, Omaha, NE (US);
Barrett Rabinow, Skokie, IL (US);
James E. Kipp, Wauconda, IL (US);
Howard Gendelman, Omaha, NE (US);
BAXTER INTERNATIONAL INC., Deerfield, IL (US);
BAXTER HEALTHCARE SA, Glattpark (Opfikon), CH;
Board of Regents of the University of Nebraska by and Behalf of the University of Nebraska Medical Center, Lincoln, NE (US);
Abstract
The present invention is concerned with delivering a pharmaceutical composition to the brain of a mammalian subject for treating brain diseases or disorders. The process includes the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns, and (ii) administering the dispersion to the mammalian subject for delivery to the brain of a portion of the pharmaceutical composition by cells capable of reaching the brain. The dispersion of the pharmaceutical composition as particles, for example, can be phagocytized or adsorbed by the cells prior or subsequent to administration into the mammalian subject. The dispersion of the pharmaceutical composition can be administered to the central nervous system or the vascular system. After administration, the loaded cells transport the pharmaceutical composition as particles into the brain.