The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 26, 2015

Filed:

Apr. 20, 2011
Applicants:

Michael Van Zandt, Branford, CT (US);

Adam Golebiowski, Branford, CT (US);

Min Koo Ji, Branford, CT (US);

Darren Whitehouse, Branford, CT (US);

Todd Ryder, Branford, CT (US);

Paul Beckett, Branford, CT (US);

Inventors:

Michael Van Zandt, Branford, CT (US);

Adam Golebiowski, Branford, CT (US);

Min Koo Ji, Branford, CT (US);

Darren Whitehouse, Branford, CT (US);

Todd Ryder, Branford, CT (US);

Paul Beckett, Branford, CT (US);

Assignee:

Mars, Incorporated, McLean, VA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07F 5/02 (2006.01); A61K 31/69 (2006.01); A61P 9/00 (2006.01); A61P 1/00 (2006.01); A61P 37/00 (2006.01); A61P 31/00 (2006.01); A61P 11/00 (2006.01); A61P 9/12 (2006.01); A61P 9/10 (2006.01); A61P 19/02 (2006.01); A61P 21/04 (2006.01); A61P 25/00 (2006.01); A61P 31/18 (2006.01); A61P 1/04 (2006.01); A61P 17/06 (2006.01); A61P 29/00 (2006.01); A61P 17/02 (2006.01); A61P 15/00 (2006.01); C12N 9/99 (2006.01);
U.S. Cl.
CPC ...
C07F 5/025 (2013.01);
Abstract

Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R, R, R, R, R, R, R, R, R, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.


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