The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2015
Filed:
Nov. 10, 2011
Applicants:
Eleonora Kiss, Brussels, BE;
Erwin Blomsma, Linden, BE;
Serge DE Bruijn, Weert, NL;
E. J. N. Remy Litjens, Heeze, NL;
Inventors:
Eleonora Kiss, Brussels, BE;
Erwin Blomsma, Linden, BE;
Serge De Bruijn, Weert, NL;
E. J. N. Remy Litjens, Heeze, NL;
Assignee:
Aratana Therapeutics NV, Heverlee, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 313/06 (2006.01); C07D 239/34 (2006.01); C07D 239/42 (2006.01); C07D 473/18 (2006.01); C07D 473/40 (2006.01);
U.S. Cl.
CPC ...
C07D 473/18 (2013.01); C07D 473/40 (2013.01);
Abstract
The present invention relates to the preparation of cyclopropane derivatives, in particular 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-4,8-dihydro-1H-purin-6-one, especially via the [(1S,7R)-4-phenyl-3,5-dioxabicyclo[5.1.0]octan-1-yl]methanol intermediate.