The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2015
Filed:
Apr. 08, 2004
Kenneth Hinds, Erdenheim, PA (US);
Danny Lewis, Hartselle, AL (US);
Paul Schmidt, Niwot, CO (US);
Kathleen M. Campbell, Longmont, CO (US);
Kenneth Hinds, Erdenheim, PA (US);
Danny Lewis, Hartselle, AL (US);
Paul Schmidt, Niwot, CO (US);
Kathleen M. Campbell, Longmont, CO (US);
AntriaBio, Inc., Louisville, CO (US);
Abstract
The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.