The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2015
Filed:
Jul. 23, 2013
Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);
Rajinder Singh, Belmont, CA (US);
Andy Atuegbu, Dublin, CA (US);
John Ramphal, Union City, CA (US);
Hui Li, Santa Clara, CA (US);
Marina Gelman, San Francisco, CA (US);
Jeffrey Clough, Redwood City, CA (US);
Carlos Valdez, San Ramon, CA (US);
Somasekhar Bhamidipati, Foster City, CA (US);
Sambaiah Thota, Woburn, MA (US);
Darren McMurtrie, Foster City, CA (US);
Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);
Abstract
Disclosed embodiments provide pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.