The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2015
Filed:
May. 19, 2011
Todd R. Klaenhammer, Raleigh, NC (US);
Richard L. Guerrant, Charlottesville, VA (US);
Glynis L. Kolling, Scottsville, VA (US);
Evelyn Durmaz, Cary, NC (US);
Michael P. Timko, Charlottesville, VA (US);
Cirle Alcantara Warren, Waynesboro, VA (US);
Todd R. Klaenhammer, Raleigh, NC (US);
Richard L. Guerrant, Charlottesville, VA (US);
Glynis L. Kolling, Scottsville, VA (US);
Evelyn Durmaz, Cary, NC (US);
Michael P. Timko, Charlottesville, VA (US);
Cirle Alcantara Warren, Waynesboro, VA (US);
North Carolina State University, Raleigh, NC (US);
University of Virginia Patent Foundation, Charlottesvile, VA (US);
Abstract
Methods and compositions for targeted delivery of biotherapeutics are provided. The compositions comprise bile-sensitivebacteria modified to release a biotherapeutic agent following bile exposure. Biotherapeutic agents released by thebacteria disclosed herein include AQ and AQR rich peptides. Methods of the invention comprise administering to a subject abacterium modified to release a biotherapeutic agent following bile exposure. Administration of thebacterium promotes a desired therapeutic response. The bacterium may be modified to express and release AQ or AQR rich peptides which subsequently inhibit cellular apoptosis or reduce mucosal damage. Thus, methods of the invention find use in treating or preventing a variety of gastrointestinal disorders includinginfection and antibiotic-associated diarrhea.