The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2015
Filed:
May. 23, 2013
Applicant:
The Trustees of Columbia University IN the City of New York, New York, NY (US);
Inventors:
Benjamin Simon Elkin, Toronto, CA;
Barclay Morrison, III, New York, NY (US);
John Desmond Finan, New York, NY (US);
Assignee:
The Trustees of Columbia University in the City of New York, New York, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/46 (2006.01); A61K 38/47 (2006.01); A61K 38/51 (2006.01); A61K 38/54 (2006.01);
U.S. Cl.
CPC ...
A61K 38/54 (2013.01); A61K 38/47 (2013.01); A61K 38/46 (2013.01); A61K 38/465 (2013.01); A61K 38/51 (2013.01);
Abstract
Tissue fixed charge density (FCD) is identified as another potential therapeutic target for reducing brain tissue swelling. Reduction of the FCD could reduce the thermodynamic force driving water entry into the brain. The present invention discloses chondroitinase ABC (ChABC) reduces tissue FCD and reduces tissue swelling, indicating that it may be an effective treatment to reduce edema and control intracranial pressure.