The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2015
Filed:
Nov. 27, 2012
Applicant:
Signature Therapeutics, Inc., San Carlos, CA (US);
Inventors:
Thomas E. Jenkins, Half Moon Bay, CA (US);
Craig O. Husfeld, San Mateo, CA (US);
Julie D. Seroogy, San Carlos, CA (US);
Jonathan W. Wray, San Francisco, CA (US);
Assignee:
Signature Therapeutics, Inc., Palo Alto, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/74 (2006.01); A61K 47/48 (2006.01); A61K 9/51 (2006.01); A61K 31/485 (2006.01); C07D 489/02 (2006.01); C07D 489/08 (2006.01); C12Q 1/37 (2006.01); G01N 33/50 (2006.01); G01N 33/94 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48246 (2013.01); A61K 9/51 (2013.01); A61K 31/485 (2013.01); A61K 47/4813 (2013.01); C07D 489/02 (2013.01); C07D 489/08 (2013.01); C12Q 1/37 (2013.01); G01N 33/5088 (2013.01); G01N 33/9486 (2013.01); G01N 2333/976 (2013.01); G01N 2500/00 (2013.01);
Abstract
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an opioid prodrug that provides enzymatically-controlled release of an opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the opioid from the opioid prodrug so as to attenuate enzymatic cleavage of the opioid prodrug.