The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2015
Filed:
Jun. 22, 2011
Lynn Macdonald, White Plains, NY (US);
Sean Stevens, San Francisco, CA (US);
Cagan Gurer, Valhalla, NY (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Karolina A. Hosiawa, Tarrytown, NY (US);
Lynn MacDonald, White Plains, NY (US);
Sean Stevens, San Francisco, CA (US);
Cagan Gurer, Valhalla, NY (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Karolina A. Hosiawa, Tarrytown, NY (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an episome wherein the hVλ sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided.