The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2015
Filed:
Sep. 28, 2012
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Jean-Damien Charrier, Grove Wantage, GB;
John Studley, Witney, GB;
Francoise Yvonne Theodora Marie Pierard, Abingdon, GB;
Steven John Durrant, Abingdon, GB;
Benjamin Joseph Littler, Carlsbad, CA (US);
Robert Michael Hughes, San Diego, CA (US);
David Andrew Siesel, San Diego, CA (US);
Paul Angell, Carlsbad, CA (US);
Armando Urbina, San Diego, CA (US);
Yi Shi, Natick, MA (US);
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Abstract
The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.