The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2015

Filed:

Aug. 19, 2010
Applicants:

Fan Wang, Hamilton, CA;

Kevin W. Kells, Cambridge, CA;

Kaarina Milnes, London, CA;

Cameron L. Mcphail, Brantford, CA;

Inventors:

Fan Wang, Hamilton, CA;

Kevin W. Kells, Cambridge, CA;

Kaarina Milnes, London, CA;

Cameron L. McPhail, Brantford, CA;

Assignee:

APOTEX PHARMACHEM INC., Brantford, CA;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); C07D 401/12 (2006.01); A61K 31/4439 (2006.01); C07D 235/28 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 235/28 (2013.01); A61K 31/4439 (2013.01);
Abstract

Provided is dexlansoprazole propylene glycolate hydrate. Polymorphic forms thereof are also provided. The dexlansoprazole propylene glycolate hydrate maybe such that the propylene glycol component is present in approximately equal proportions of (R) absolute configuration and (S) absolute configuration, or present in predominantly (R) absolute configuration, or predominantly (S) absolute configuration. Salts of dexlansoprazole are also provided. In particular, crystalline dexlansoprazole isopropylammonium salt and crystalline MTBE solvate of dexlansoprazole t-butylammonium salt are provided. Pharmaceutical formulations comprising dexlansoprazole propylene glycolate hydrate are also provided. Furthermore, processes for preparation of dexlansoprazole propylene glycolate hydrate are provided.


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