The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2015
Filed:
May. 01, 2009
Jason David Oliver, Wilmslow, GB;
John Leslie Thain, Manchester, GB;
Michael John Bromley, Halifax, GB;
Graham Edward Morris Sibley, Manchester, GB;
Michael Birch, Manchester, GB;
Jason David Oliver, Wilmslow, GB;
John Leslie Thain, Manchester, GB;
Michael John Bromley, Halifax, GB;
Graham Edward Morris Sibley, Manchester, GB;
Michael Birch, Manchester, GB;
F2G Limited, Manchester, GB;
Abstract
A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concernandDHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.