The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2015
Filed:
Sep. 14, 2012
Kamlesh Jagdis Bala, Horsham, GB;
Rebecca Butler, Horsham, GB;
Stephen Paul Collingwood, Haywards Heath, GB;
Edward Charles Hall, Horsham, GB;
Lee Edwards, Partridge Green, GB;
Darren Mark Legrand, East Grinstead, GB;
Katrin Spiegel, Horsham, GB;
Kamlesh Jagdis Bala, Horsham, GB;
Rebecca Butler, Horsham, GB;
Stephen Paul Collingwood, Haywards Heath, GB;
Edward Charles Hall, Horsham, GB;
Lee Edwards, Partridge Green, GB;
Darren Mark Legrand, East Grinstead, GB;
Katrin Spiegel, Horsham, GB;
Novartis AG, Basel, CH;
Abstract
The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.