The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2015

Filed:

Jun. 12, 2008
Applicants:

Christian Poulsen, København K, DK;

Kasper Huus, København V, DK;

Frantisek Hubalek, Herlev, DK;

Dorte Bjerre Steensgaard, Københabn Ø, DK;

Svend Havelund, Bagsværd, DK;

Inventors:

Christian Poulsen, København K, DK;

Kasper Huus, København V, DK;

Frantisek Hubalek, Herlev, DK;

Dorte Bjerre Steensgaard, Københabn Ø, DK;

Svend Havelund, Bagsværd, DK;

Assignee:

Novo Nordisk A/S, Bagsvaerd, DK;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/28 (2006.01); A61K 9/00 (2006.01); C07K 14/62 (2006.01); A61K 9/08 (2006.01); A61K 31/315 (2006.01); A61K 33/30 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2006.01); A61K 47/12 (2006.01); A61K 47/18 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0019 (2013.01); C07K 14/62 (2013.01); A61K 9/08 (2013.01); A61K 31/315 (2013.01); A61K 33/30 (2013.01); A61K 38/28 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/18 (2013.01); A61K 47/183 (2013.01);
Abstract

The invention concerns a soluble pharmaceutical formulation comprising an insulin derivative wherein the formulation further comprises more than 4 zinc atoms per 6 molecules of the insulin derivative, and a citric acid monohydrate and/or a histidine compound used in an amount sufficient to increase the tendency of the insulin derivative to self-associate into dodecamers. The invention further comprises a process for preparing the soluble pharmaceutical formulation.


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