The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2015
Filed:
Dec. 17, 2013
Applicant:
Conaris Research Institute Ag, Kiel, DE;
Inventors:
Georg H. Wätzig, Kiel, DE;
Dirk Seegert, Altenholz, DE;
Assignee:
CONARIS RESEARCH INSTITUTE AG, Kiel, DE;
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2006.01); C07K 16/24 (2006.01); A61K 38/20 (2006.01); C07K 14/715 (2006.01);
U.S. Cl.
CPC ...
C07K 16/248 (2013.01); A61K 38/204 (2013.01); C07K 14/7155 (2013.01); C07K 2319/30 (2013.01);
Abstract
Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala-Glu-Gly-Ala. Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.