The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2015

Filed:

Apr. 05, 2008
Applicants:

Matthias Merz, Leuven, BE;

Youri V. Ponomarev, Leuven, BE;

Gilberto Curatola, Korbek-Lo, BE;

Inventors:

Matthias Merz, Leuven, BE;

Youri V. Ponomarev, Leuven, BE;

Gilberto Curatola, Korbek-Lo, BE;

Assignee:

NXP, B.V., Eindhoven, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/34 (2006.01); C12M 1/00 (2006.01); C12M 3/00 (2006.01); G01R 31/26 (2014.01); H01L 21/66 (2006.01); G01N 33/487 (2006.01); C12Q 1/68 (2006.01); G01N 27/414 (2006.01);
U.S. Cl.
CPC ...
G01N 33/48721 (2013.01); C12Q 1/6869 (2013.01); G01N 27/414 (2013.01);
Abstract

A detector device comprises a substrate (), a source region (S) and a drain region (D), and a channel region () between the source and drain regions. A nanopore () passes through the channel region, and connects fluid chambers () on opposite sides of the substrate. A voltage bias is provided between the fluid chambers, the source and drain regions and a charge flow between the source and drain regions is sensed. The device uses a nanopore for the confinement of a sample under test (for example nucleotides) close to a sensor. The size of the sensor can be made similar to the spacing of adjacent nucleotides in a DNA strand. In this way, the disadvantages of PCR based techniques for DNA sequencing are avoided, and single nucleotide resolution can be attained.


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