The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2015
Filed:
Jun. 04, 2010
Matteo D'este, Abano Terme, IT;
Davide Renier, Abano Terme, IT;
Gianfranco Pasut, Abano Terme, IT;
Antonio Rosato, Abano Terme, IT;
Matteo D'Este, Abano Terme, IT;
Davide Renier, Abano Terme, IT;
Gianfranco Pasut, Abano Terme, IT;
Antonio Rosato, Abano Terme, IT;
FIDIA FARMACEUTICI S.P.A., Abano Terme, IT;
Abstract
The present invention relates to a process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules of varying nature, comprising small molecules and macro-molecules. In particular, the present invention relates to the conjugation of hyaluronic acid (HA) and its derivatives with polypeptides and proteins with a biological action, such as, for example, interferons, erythropoietins, growth factors, insulin, cytokines, antibodies and hormones. An object of the present invention also relates to isolatable intermediates obtained by the partial or total reaction of GAG with protected amino aldehydes in the conjugation process mentioned above.