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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9034348 B1

PDFFull Text
Date of Patent:
May. 19, 2015

Filed:

Mar. 14, 2013

Injectable chitosan mixtures forming hydrogels

Applicant:

Chi2gel Ltd., Tel Aviv, IL;

Inventors:

Noah Ben-Shalom, Tel Aviv, IL;

Zvi Nevo, Herzlia, IL;

Abraham Patchornik, Nes Ziona, IL;

Dror Robinson, Kfar-Shmuel-Doar-Na Shimshon, IL;

Assignee:

Chi2Gel Ltd., Tel Aviv, IL;

Attorney:

Winston & Strawn LLP

Primary Examiner:

Benjamin Packard

Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 47/36 (2006.01); A61L 26/00 (2006.01); A61K 31/738 (2006.01); A61L 27/20 (2006.01); A61L 27/52 (2006.01); A61L 27/60 (2006.01); A61K 8/73 (2006.01); A61Q 19/00 (2006.01); A61K 9/06 (2006.01); A61K 8/04 (2006.01); C08J 3/075 (2006.01); C08L 5/08 (2006.01); A61L 27/38 (2006.01); A61Q 19/08 (2006.01);
U.S. Cl.
CPC ...
A61K 47/36 (2013.01); A61L 26/0023 (2013.01); A61K 31/738 (2013.01); A61L 27/20 (2013.01); A61L 27/52 (2013.01); A61L 27/60 (2013.01); A61K 8/736 (2013.01); A61Q 19/00 (2013.01); A61K 9/0009 (2013.01); A61K 9/0014 (2013.01); A61K 9/0024 (2013.01); A61K 9/06 (2013.01); A61K 8/042 (2013.01); C08J 3/075 (2013.01); C08L 5/08 (2013.01); A61K 2800/594 (2013.01); A61K 2800/91 (2013.01); A61L 2400/06 (2013.01); C08J 2305/08 (2013.01); A61K 2800/805 (2013.01); A61L 27/3804 (2013.01); A61L 26/008 (2013.01); A61Q 19/08 (2013.01);
Abstract

A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.

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