The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2015
Filed:
Jan. 10, 2006
Mario H. Skiadopoulos, Potomac, MD (US);
Brian R. Murphy, Bethesda, MD (US);
Peter L. Collins, Silver Spring, MD (US);
Sheila Nolan, Pleasantville, NY (US);
Mario H. Skiadopoulos, Potomac, MD (US);
Brian R. Murphy, Bethesda, MD (US);
Peter L. Collins, Silver Spring, MD (US);
Sheila Nolan, Pleasantville, NY (US);
Abstract
The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.