The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2015

Filed:

Feb. 08, 2011
Applicants:

David B Weiner, Merion, PA (US);

Jean D Boyer, Haddonfield, NJ (US);

Michele Kutzler, Souderton, PA (US);

Inventors:

David B Weiner, Merion, PA (US);

Jean D Boyer, Haddonfield, NJ (US);

Michele Kutzler, Souderton, PA (US);

Assignees:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/49 (2006.01); C12N 15/63 (2006.01); A61K 31/7088 (2006.01); C07K 14/52 (2006.01); A61K 39/21 (2006.01); C07K 14/47 (2006.01); C07K 14/435 (2006.01); A61K 48/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/523 (2013.01); C07H 21/04 (2013.01); A61K 31/7088 (2013.01); A61K 48/00 (2013.01); C07K 14/435 (2013.01); C07K 14/47 (2013.01); C12N 2740/16011 (2013.01); C12N 2740/16034 (2013.01); C12N 15/63 (2013.01); A61K 39/21 (2013.01); A61K 2039/53 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55538 (2013.01); A61K 2039/57 (2013.01); C12N 2740/15034 (2013.01);
Abstract

Nucleic acid molecules comprising a nucleotide sequence encoding RANTES and fragments and variants thereof are disclosed. Additionally, nucleic acid molecules and compositions comprising the nucleotide sequence encoding RANTES and fragments and variants thereof in combination with nucleic acid sequences encoding immunogens are provided. Recombinant viral vectors comprising the nucleotide sequence encoding RANTES and fragments and variants thereof with or without a nucleic acid sequence encoding immunogens are also provided as are live attenuated pathogens comprising a nucleotide sequence encoding RANTES and fragments and variants thereof. Methods of modulating immune responses and of inducing an immune response against an immunogen are also disclosed.


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