The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 12, 2015

Filed:

Mar. 27, 2006
Applicants:

Darrell O. Wagner, Isanti, MN (US);

Haris J. Sih, Minneapolis, MN (US);

Jihong Qu, Maple Grove, MN (US);

Jeffrey Ross, Roseville, MN (US);

Steven D. Girouard, Chagrin Falls, OH (US);

Ronald W. Heil, Jr., Roseville, MN (US);

Inventors:

Darrell O. Wagner, Isanti, MN (US);

Haris J. Sih, Minneapolis, MN (US);

Jihong Qu, Maple Grove, MN (US);

Jeffrey Ross, Roseville, MN (US);

Steven D. Girouard, Chagrin Falls, OH (US);

Ronald W. Heil, Jr., Roseville, MN (US);

Assignee:

Cardiac Pacemakers, Inc., St. Paul, MN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/48 (2006.01); A61K 48/00 (2006.01); A61N 1/05 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0008 (2013.01); A61K 48/0083 (2013.01); A61N 1/05 (2013.01);
Abstract

A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.


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