The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2015
Filed:
Jul. 22, 2011
Applicants:
Graham Mcgowan, Toronto, CA;
Boris Gorin, Oakville, CA;
Bruce Goodbrand, Hamilton, CA;
Elena Bejan, Brantford, CA;
Inventors:
Graham McGowan, Toronto, CA;
Boris Gorin, Oakville, CA;
Bruce Goodbrand, Hamilton, CA;
Elena Bejan, Brantford, CA;
Assignee:
Alphora Research Inc., Mississauga, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 45/61 (2006.01); C07C 45/67 (2006.01); C07C 45/71 (2006.01); C07C 47/575 (2006.01);
U.S. Cl.
CPC ...
C07C 45/61 (2013.01); C07C 45/67 (2013.01); C07C 45/71 (2013.01); C07C 47/575 (2013.01);
Abstract
A para-methoxy protected benzaldehyde useful in preparation of treprostinil, and of formula: (Formula (1)) is prepared by subjecting to Claisen re-arrangement a substituted benzaldehyde of formula (1a): (Formula (Ia)) to form the m-hydroxy-substituted benzaldehyde of formula (1b): (Formula (Ib)) and then reacting compound (1b) with a p-methoxybenzyl (PMB) compound to form a PMB-substituted benzaldehyde of formula (1).