The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2015
Filed:
Mar. 12, 2012
Hans-georg Lerchen, Leverkusen, DE;
Sherif El Sheikh, Essen, DE;
Beatrix Stelte-ludwig, Wülfrath, DE;
Joachim Schuhmacher, Wuppertal, DE;
Mark Gnoth, Mettmann, DE;
Hans-Georg Lerchen, Leverkusen, DE;
Sherif El Sheikh, Essen, DE;
Beatrix Stelte-Ludwig, Wülfrath, DE;
Joachim Schuhmacher, Wuppertal, DE;
Mark Gnoth, Mettmann, DE;
Seattle Genetics, Inc, Bothell, WA (US);
Abstract
The present application relates to new derivatives, substituted on the N terminus by a carboxyalkyl group, of monomethylauristatin E and monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and to the use of these derivatives for producing medicaments for treating and/or preventing diseases, more particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments may be applied as a monotherapy or else in combination with other medicaments or further therapeutic measures.