The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2015
Filed:
Jul. 22, 2011
Applicants:
Shawn Edward Lupold, Ellicott City, MD (US);
Theodore L. Deweese, Baltimore, MD (US);
Xiaohua NI, Baltimore, MD (US);
Yonggang Zhang, Nottingham, MD (US);
Inventors:
Shawn Edward Lupold, Ellicott City, MD (US);
Theodore L. DeWeese, Baltimore, MD (US);
Xiaohua Ni, Baltimore, MD (US);
Yonggang Zhang, Nottingham, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 38/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01);
Abstract
Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of radiosensitizing genes in neoplastic cells expressing a cell surface molecule that binds the aptamer.