The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2015
Filed:
May. 23, 2012
Applicants:
Gordon D. Webster, Cambridge, MA (US);
Suzanne P. Mckenzie, West Newton, MA (US);
Kin-ming Lo, Lexington, MA (US);
Pascal André Stein, Boston, MA (US);
Inventors:
Gordon D. Webster, Cambridge, MA (US);
Suzanne P. McKenzie, West Newton, MA (US);
Kin-Ming Lo, Lexington, MA (US);
Pascal André Stein, Boston, MA (US);
Assignee:
Merck Patent GmbH, Darmstadt, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 35/00 (2006.01); H04N 21/61 (2011.01); H04N 21/462 (2011.01); H04N 21/8549 (2011.01); C07H 21/04 (2006.01); C12N 1/21 (2006.01); C12N 5/16 (2006.01); C12P 21/04 (2006.01); C12N 15/09 (2006.01); C07K 14/54 (2006.01); C07K 19/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
H04N 21/6106 (2013.01); A61K 38/00 (2013.01); C07K 14/5434 (2013.01); H04N 21/462 (2013.01); H04N 21/8549 (2013.01);
Abstract
Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.