The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2015
Filed:
Mar. 24, 2011
Steven M. Jay, Cambridge, MA (US);
Linda G. Griffith, Cambridge, MA (US);
Richard T. Lee, Weston, MA (US);
Steven M. Jay, Cambridge, MA (US);
Linda G. Griffith, Cambridge, MA (US);
Richard T. Lee, Weston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The invention provides methods and compositions for reducing, preventing or reversing cardio toxicity side effects associated with certain therapeutic agents. The invention also provides methods and compositions for treating heart dysfunction including heart failure, and for reversing the effects of myocardial infarction. The various aspects of the invention involve the use of ligand dimers, such as neuregulin dimers, that selectively induce the dimerization of certain EGF receptors in cardiac tissue.