The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2015
Filed:
Jun. 13, 2008
Applicants:
Clark K. Colton, Newton, MA (US);
Daryl E. Powers, Cambridge, MA (US);
Jeffrey R. Millman, Cambridge, MA (US);
Inventors:
Clark K. Colton, Newton, MA (US);
Daryl E. Powers, Cambridge, MA (US);
Jeffrey R. Millman, Cambridge, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/02 (2006.01); C12N 5/00 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0657 (2013.01); C12N 2500/25 (2013.01); C12N 2500/34 (2013.01); C12N 2500/38 (2013.01); C12N 2501/235 (2013.01); C12N 2506/02 (2013.01); C12N 2533/30 (2013.01);
Abstract
The invention provides methods for differentiating pluripotent stem cells such as ES cells with improved progenitor and differentiated cell yield using low oxygen conditions and optionally in the absence of exogenously added differentiation factors.