The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2015
Filed:
Aug. 16, 2012
Allan Svendsen, Hoersholm, DK;
Michael Skjoet, Jyllinge, DK;
Deborah Yaver, Davis, CA (US);
Lars Lehmann Hylling Christensen, Alleroed, DK;
Signe Eskildsen Larsen, Lyngby, DK;
Nina Lundin, Frederiksberg, DK;
Michael Lamsa, Davis, CA (US);
Peter Colin Gregory, Hannover, DE;
Allan Svendsen, Hoersholm, DK;
Michael Skjoet, Jyllinge, DK;
Deborah Yaver, Davis, CA (US);
Lars Lehmann Hylling Christensen, Alleroed, DK;
Signe Eskildsen Larsen, Lyngby, DK;
Nina Lundin, Frederiksberg, DK;
Michael Lamsa, Davis, CA (US);
Peter Colin Gregory, Hannover, DE;
Novozymes A/S, Bagsvaerd, DK;
Novozymes Inc, Davis, CA (US);
Abstract
The pharmaceutical use of lipases related to the() lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have, e.g., an improved digestion performance in vitro, an improved activity at a pH in the neutral range, an improved stability at low pH, and are stable against protease-degradation, and/or are stable in the presence of pepsin and bile salts. The invention also relates to methods of determining digestion performance in vitro of lipases, as well as to certain novel variants of the lipase of