The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2015
Filed:
Jul. 13, 2011
Neil D. Brewis, Hauxton, GB;
Benjamin P. Woolven, Bedford, GB;
Steve Holmes, Great Chishill, GB;
Ian M. Tomlinson, Great Shelford, GB;
Jennifer Lee, Cambridge, GB;
Carolyn Enever, Cambridge, GB;
Amrik Basran, Cambridge, GB;
Kate Jones, Cambridge, GB;
Ruud DE Wildt, Cambridge, GB;
Stanislas Blein, Briancon, FR;
Neil D. Brewis, Hauxton, GB;
Benjamin P. Woolven, Bedford, GB;
Steve Holmes, Great Chishill, GB;
Ian M. Tomlinson, Great Shelford, GB;
Jennifer Lee, Cambridge, GB;
Carolyn Enever, Cambridge, GB;
Amrik Basran, Cambridge, GB;
Kate Jones, Cambridge, GB;
Ruud de Wildt, Cambridge, GB;
Stanislas Blein, Briancon, FR;
Domantis Limited, Brentford, Middlesex, GB;
Abstract
The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands.