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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9024032 B1

PDFFull Text
Date of Patent:
May. 05, 2015

Filed:

Feb. 28, 2011

Inhibitors of catechol o-methyl transferase and their use in the treatment of psychotic disorders

Applicants:

Scott Wolkenberg, Wyndmoor, PA (US);

James C. Barrow, Arnold, MD (US);

Michael S. Poslusney, Nashville, TN (US);

Scott T. Harrison, Glenside, PA (US);

B. Wesley Trotter, Medfield, MA (US);

James Mulhearn, Elkins Park, PA (US);

Kausik K. Nanda, Norristown, PA (US);

Peter J. Manley, Harleysville, PA (US);

Zhijian Zhao, Wilmington, DE (US);

Jeffrey W. Schubert, Ambler, PA (US);

Nathan Kett, Columbia, TN (US);

Amy Zartman, Hatfield, PA (US);

Inventors:

Scott Wolkenberg, Wyndmoor, PA (US);

James C. Barrow, Arnold, MD (US);

Michael S. Poslusney, Nashville, TN (US);

Scott T. Harrison, Glenside, PA (US);

B. Wesley Trotter, Medfield, MA (US);

James Mulhearn, Elkins Park, PA (US);

Kausik K. Nanda, Norristown, PA (US);

Peter J. Manley, Harleysville, PA (US);

Zhijian Zhao, Wilmington, DE (US);

Jeffrey W. Schubert, Ambler, PA (US);

Nathan Kett, Columbia, TN (US);

Amy Zartman, Hatfield, PA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Fox Rothschild LLP

Gerard P. Norton

Jin Zhu

Primary Examiner:

Heidi Reese

Int. Cl.
CPC ...
A61K 31/44 (2006.01); C07D 211/90 (2006.01); C07D 213/69 (2006.01); A61K 31/4412 (2006.01); A61K 31/4418 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61K 31/69 (2006.01); A61K 45/06 (2006.01); C07D 213/73 (2006.01); C07D 213/74 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 417/10 (2006.01); C07D 471/04 (2006.01); C07F 5/02 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01);
U.S. Cl.
CPC ...
C07D 213/69 (2013.01); A61K 31/4412 (2013.01); A61K 31/4418 (2013.01); A61K 31/4439 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/69 (2013.01); A61K 45/06 (2013.01); C07D 213/73 (2013.01); C07D 213/74 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 417/10 (2013.01); C07D 471/04 (2013.01); C07F 5/025 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01);
Abstract

The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.

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