The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2015
Filed:
Jan. 26, 2012
Applicants:
Feng LI, Winchester, MA (US);
Yihan Wang, Newtown, MA (US);
Inventors:
Feng Li, Winchester, MA (US);
Yihan Wang, Newtown, MA (US);
Assignee:
ARIAD Pharmaceuticals, Inc., Cambridge, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/60 (2006.01); C07C 51/06 (2006.01); C07C 209/08 (2006.01); C07C 231/02 (2006.01); C07C 235/34 (2006.01); C07D 205/04 (2006.01); C07D 319/06 (2006.01); C07D 319/04 (2006.01); C07B 53/00 (2006.01); C07C 209/62 (2006.01); C07C 209/74 (2006.01); C07C 231/18 (2006.01);
U.S. Cl.
CPC ...
C07D 211/60 (2013.01); C07D 205/04 (2013.01); C07D 319/04 (2013.01); C07B 53/00 (2013.01); C07C 209/08 (2013.01); C07C 209/62 (2013.01); C07C 209/74 (2013.01); C07C 231/02 (2013.01); C07C 231/18 (2013.01); C07C 235/34 (2013.01); C07C 51/06 (2013.01); C07D 319/06 (2013.01); C07B 2200/07 (2013.01);
Abstract
The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.