The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2015
Filed:
Nov. 25, 2013
Applicant:
Curis, Inc., Lexington, MA (US);
Inventors:
Changgeng Qian, Wayland, MA (US);
Xiong Cai, Bedford, MA (US);
Stephen Gould, San Carlos, CA (US);
Haixiao Zhai, Bedford, MA (US);
Assignee:
Curis, Inc., Lexington, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/94 (2006.01); C07D 403/12 (2006.01); C07D 405/04 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01);
U.S. Cl.
CPC ...
C07D 239/94 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/04 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01);
Abstract
The present invention relates to quinazoline containing zinc-binding moiety based derivatives of Formula (IV) below. These compounds have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and are useful in the treatment of EGFR-TK related diseases and disorders such as cancer. These compounds may further act as HDAC inhibitors.