The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2015
Filed:
Dec. 23, 2010
Ludger Grosse-hovest, Tuebingen, DE;
Hans-joerg Buehring, Tuebingen, DE;
Martin Hofmann, Tuebingen, DE;
Steffen Aulwurm, Hechingen, DE;
Grundram Jung, Rottenburg-Wendelsheim, DE;
Ludger Grosse-Hovest, Tuebingen, DE;
Hans-Joerg Buehring, Tuebingen, DE;
Martin Hofmann, Tuebingen, DE;
Steffen Aulwurm, Hechingen, DE;
Grundram Jung, Rottenburg-Wendelsheim, DE;
Synimmune GmbH, Tuebingen, DE;
Abstract
The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitutions 239D and 332E to enhance antibody-dependent cell cytotoxicity (ADCC) of these antibodies. The invention further relates to pharmaceutical compositions containing these antibodies, nucleic acids encoding these antibodies as well as methods of using such antibodies.