The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 05, 2015

Filed:

Dec. 28, 2007
Applicants:

John C. Hutton, Denver, CO (US);

Janet M. Wenzlau, Greenwood Village, CO (US);

Jan Jensen, Shaker Heights, OH (US);

Howard Davidson, Denver, CO (US);

Inventors:

John C. Hutton, Denver, CO (US);

Janet M. Wenzlau, Greenwood Village, CO (US);

Jan Jensen, Shaker Heights, OH (US);

Howard Davidson, Denver, CO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); C07K 14/705 (2006.01); C07K 14/47 (2006.01); G01N 33/564 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); C07K 14/47 (2013.01); G01N 33/564 (2013.01); G01N 2800/042 (2013.01); G01N 2800/52 (2013.01);
Abstract

Described is the identification of ZnT8 as an autoantigen target in type I autoimmune diabetes (T1D), other autoimmune disease, and other diabetes-linked diseases and conditions. Also described are a variety of therapeutic, diagnostic, and prognostic tools and methods based on this discovery. The identification of genetic variation in ZnT8 as an important player in the initiation of the disease process and the progression of autoimmunity to clinical diabetes is disclosed.


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