The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 05, 2015

Filed:

Jun. 12, 2012
Applicants:

Kazuo Shimizu, Azumino, JP;

Yasushi Takigawa, Azumino, JP;

Hideki Fujikura, Azumino, JP;

Masato Iizuka, Azumino, JP;

Masahiro Hiratochi, Azumino, JP;

Norihiko Kikuchi, Azumino, JP;

Inventors:

Kazuo Shimizu, Azumino, JP;

Yasushi Takigawa, Azumino, JP;

Hideki Fujikura, Azumino, JP;

Masato Iizuka, Azumino, JP;

Masahiro Hiratochi, Azumino, JP;

Norihiko Kikuchi, Azumino, JP;

Assignee:

Kissei Pharmaceutical Co., Ltd., Matsumoto-shi, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4025 (2006.01); C07D 231/10 (2006.01); C07D 207/30 (2006.01); A61K 31/4155 (2006.01); C07D 403/04 (2006.01); A61K 31/402 (2006.01); A61K 31/165 (2006.01); A61K 31/404 (2006.01); A61K 31/415 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 207/34 (2006.01); C07D 231/14 (2006.01); C07D 231/16 (2006.01); C07D 231/20 (2006.01); C07D 231/38 (2006.01); C07D 231/40 (2006.01); C07D 401/04 (2006.01); C07D 405/04 (2006.01); C07D 405/06 (2006.01); C07D 409/04 (2006.01); C07D 409/12 (2006.01); C07D 417/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/402 (2013.01); A61K 31/165 (2013.01); A61K 31/404 (2013.01); A61K 31/415 (2013.01); A61K 31/4155 (2013.01); A61K 31/427 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 207/34 (2013.01); C07D 231/14 (2013.01); C07D 231/16 (2013.01); C07D 231/20 (2013.01); C07D 231/38 (2013.01); C07D 231/40 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 409/04 (2013.01); C07D 409/12 (2013.01); C07D 417/04 (2013.01);
Abstract

5-membered heterocyclic derivatives represented by general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro, cyano and the like; ring J represents aryl or heteroaryl; Q represents carboxy, 5-tetazolyl and the like; Y represents H, OH, NH, halogen, haloalkyl and the like; Xand Xindependently represent CRor N; Rrepresents H, alkyl and the like; Rrepresents halogen, cyano, haloalkyl, A-D-E-G-L-M, —N(-D-L-M)and the like, A represents a single bond, O, S and the like; D, G and M independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E and L independently represent a single bond, O, S, COO, SOand the like.


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