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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9023871 B1

PDFFull Text
Date of Patent:
May. 05, 2015

Filed:

Apr. 07, 2014

Materials and methods useful to induce vacuolization, cell death, or a combination thereof

Applicant:

The University of Toledo, Toledo, OH (US);

Inventors:

William A. Maltese, Toledo, OH (US);

Paul W. Erhardt, Toledo, OH (US);

Christopher Trabbic, Toledo, OH (US);

Jean H. Overmeyer, Perrysburg, OH (US);

Assignee:

The University of Toledo, Columbus, OH (US);

Attorney:

MacMillan, Sobanski & Todd, LLC

Primary Examiner:

Timothy R Rozof

Int. Cl.
CPC ...
C07D 401/06 (2006.01); A61K 31/404 (2006.01); A61K 31/4439 (2006.01); C07D 209/12 (2006.01); A61K 45/06 (2006.01); C07D 403/06 (2006.01); C07D 209/08 (2006.01); C40B 40/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/404 (2013.01); A61K 45/06 (2013.01); A61K 31/4439 (2013.01); C07D 401/06 (2013.01); C07D 403/06 (2013.01); C07D 209/08 (2013.01); C07D 209/12 (2013.01); C40B 40/04 (2013.01);
Abstract

The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.

Find Patent Forward Citations

Maltese, William. (2015). Materials and methods useful to induce vacuolization, cell death, or a combination thereof (U.S. Patent No. 9023871). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9023871

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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