The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 05, 2015

Filed:

Oct. 25, 2012
Applicants:

Jongwon Lim, Lexington, MA (US);

Elizabeth Helen Kelley, Cambridge, MA (US);

Joey L. Methot, Westwood, MA (US);

Hua Zhou, Acton, MA (US);

Alessia Petrocchi, Houston, TX (US);

Umar Faruk Mansoor, Framingham, MA (US);

Christian Fischer, Natick, MA (US);

Brendan O'boyle, Pittsburgh, PA (US);

David Joseph Guerin, Natick, MA (US);

Corey E. Bienstock, Natick, MA (US);

Christopher W. Boyce, Flemington, NJ (US);

Matthew H. Daniels, Somerville, MA (US);

Danielle Falcone, Brookline, MA (US);

Ronald D. Ferguson, Scotch Plains, NJ (US);

Salem Fevrier, Cranford, NJ (US);

Xianhai Huang, Warren, NJ (US);

Kathryn Ann Lipford, Boston, MA (US);

David L. Sloman, Brookline, MA (US);

Kevin Wilson, Boston, MA (US);

Wei Zhou, Scotch Plains, NJ (US);

David Witter, Norfolk, MA (US);

Milana M. Maletic, Summit, NJ (US);

Phieng Siliphaivanh, Newton, MA (US);

Inventors:

Jongwon Lim, Lexington, MA (US);

Elizabeth Helen Kelley, Cambridge, MA (US);

Joey L. Methot, Westwood, MA (US);

Hua Zhou, Acton, MA (US);

Alessia Petrocchi, Houston, TX (US);

Umar Faruk Mansoor, Framingham, MA (US);

Christian Fischer, Natick, MA (US);

Brendan O'Boyle, Pittsburgh, PA (US);

David Joseph Guerin, Natick, MA (US);

Corey E. Bienstock, Natick, MA (US);

Christopher W. Boyce, Flemington, NJ (US);

Matthew H. Daniels, Somerville, MA (US);

Danielle Falcone, Brookline, MA (US);

Ronald D. Ferguson, Scotch Plains, NJ (US);

Salem Fevrier, Cranford, NJ (US);

Xianhai Huang, Warren, NJ (US);

Kathryn Ann Lipford, Boston, MA (US);

David L. Sloman, Brookline, MA (US);

Kevin Wilson, Boston, MA (US);

Wei Zhou, Scotch Plains, NJ (US);

David Witter, Norfolk, MA (US);

Milana M. Maletic, Summit, NJ (US);

Phieng Siliphaivanh, Newton, MA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 31/437 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 519/00 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01);
Abstract

Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).


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