The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2015
Filed:
Nov. 30, 2012
Applicant:
Battelle Memorial Institute, Richland, WA (US);
Inventors:
Ziyu Dai, Richland, WA (US);
Scott E. Baker, Richland, WA (US);
Assignee:
Battelle Memorial Institute, Richland, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/15 (2006.01); C12P 7/48 (2006.01); C12N 1/14 (2006.01); C12N 9/10 (2006.01); C12N 15/00 (2006.01); C12P 21/00 (2006.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
C12P 7/48 (2013.01); C12N 1/14 (2013.01); C12N 9/1051 (2013.01); C12Y 204/01258 (2013.01);
Abstract
Provided herein are fungi, such as, having a dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase (Alg3) gene genetic inactivation, increased expression of a loss of aflR expression A (Lae), or both. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain. Methods of using the disclosed fungi to make citric acid are also provided, as are compositions and kits including the disclosed fungi.