The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2015
Filed:
Jan. 16, 2014
Applicant:
Joseph P. Errico, Warren, NJ (US);
Inventors:
Joseph P. Errico, Warren, NJ (US);
Benjamin Mugrage, Cranbury, NJ (US);
Ignatius Turchi, Yardley, PA (US);
Matthew Sills, Berkeley Heights, NJ (US);
Jane Ong, Franklin Park, NJ (US);
John Allocco, Staten Island, NY (US);
Pam Wines, Manalapan, NJ (US);
Margarita Bastos, Plainsboro, NJ (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); A61K 31/4709 (2006.01); A61K 31/517 (2006.01); A61K 39/395 (2006.01); C07K 16/44 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07K 16/44 (2013.01); A61K 31/4709 (2013.01); A61K 31/517 (2013.01); A61K 39/3955 (2013.01);
Abstract
Provided is a method of treating a proliferative disease, condition, or disorder in a subject by administering a combination of an inhibitor of p53 and MDM2 binding and an EGFR inhibitor. Various embodiments of the disclosed methods provide a synergistic anti-proliferative or anti-apoptotic effect compared to administration of one agent alone.