The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 05, 2015
Filed:
Nov. 19, 2008
Antje Kahnert, Wuppertal, DE;
David Light, San Mateo, CA (US);
Doug Schneider, Lafayette, CA (US);
Renate Parry, Oakland, CA (US);
Noboru Satozawa, Chiba, JP;
Tara Renee Heitner Hansen, København, DK;
Stefan Steidl, München, DE;
Ulrike Schubert, München, DE;
Antje Kahnert, Wuppertal, DE;
David Light, San Mateo, CA (US);
Doug Schneider, Lafayette, CA (US);
Renate Parry, Oakland, CA (US);
Noboru Satozawa, Chiba, JP;
Tara Renee Heitner Hansen, København, DK;
Stefan Steidl, München, DE;
Ulrike Schubert, München, DE;
Bayer Intellectual Property GmbH, Monheim, DE;
Abstract
The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 4O.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.