The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2015
Filed:
Jun. 25, 2013
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Germaine Fuh, Pacifica, CA (US);
Hans-Peter Gerber, Bellevue, WA (US);
Wei-Ching Liang, Foster City, CA (US);
Frederic Fellouse, Toronto, CA;
Sachdev S. Sidhu, San Francisco, CA (US);
Christian Wiesmann, Brisbane, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/22 (2006.01); C07K 16/18 (2006.01); C07K 16/00 (2006.01); C07K 16/32 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61K 2039/505 (2013.01); C07K 16/005 (2013.01); C07K 16/32 (2013.01); C07K 2316/96 (2013.01); C07K 2317/31 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01); G01N 33/6845 (2013.01);
Abstract
Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.