The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2015
Filed:
Mar. 22, 2012
Ada Rephaeli, Herzliya, IL;
Nataly Tarasenko, Petah-Tikva, IL;
Zvi Malik, Kefar Haroe, IL;
Abraham Nudelman, Rehovot, IL;
Gili Berkovitch-luria, Petach-Tikva, IL;
Dvir Doron, Givat Shmuel, IL;
Ada Rephaeli, Herzliya, IL;
Nataly Tarasenko, Petah-Tikva, IL;
Zvi Malik, Kefar Haroe, IL;
Abraham Nudelman, Rehovot, IL;
Gili Berkovitch-Luria, Petach-Tikva, IL;
Dvir Doron, Givat Shmuel, IL;
Bar Ilan University, Ramat Gan, IL;
Ramot at Tel Aviv University Ltd., Tel Aviv, IL;
Abstract
The present invention provides drug conjugates comprising 5-aminolevulinic acid (ALA), an aldehyde and a carboxylic acid that may function as a histone deacetylase inhibitor (HDACI). These conjugates may serve as co-drugs which release a plurality of active species in vivo. The novel drug conjugates may be used, for the treatment or prevention of cancer in PDT-dependent and/or PDT-independent (nonPDT) treatments, as well as for cosmetic uses. In addition the present invention provides novel uses for both the novel and known compounds. According to some embodiments, the present invention provides drug conjugates (co-drugs) comprising (i) ALA, (ii) an aldehyde and (iii) a carboxylic acid that may function as a histone deacetylase inhibitor (HDACO for the treatment of anemia and/or for the induction of erythropoiesis.