The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2015
Filed:
Mar. 31, 2010
Santosh Kumar Srivastava, Lucknow, IN;
Ashok Kumar Agrawal, Lucknow, IN;
Subhash Chandra Singh, Lucknow, IN;
Vinay Kumar Khanna, Lucknow, IN;
Janardan Singh, Lucknow, IN;
Chandeshwar Nath, Lucknow, IN;
Madan Mohan Gupta, Lucknow, IN;
Shikha Gupta, Lucknow, IN;
Ram Kishor Verma, Lucknow, IN;
Anirban Pal, Lucknow, IN;
Dnyaneshwar Umrao Bawankule, Lucknow, IN;
Dharmendra Saikia, Lucknow, IN;
Anil Kumar Gupta, Lucknow, IN;
Anupam Maurya, Lucknow, IN;
Suman Preet Singh Khanuja, Lucknow, IN;
Santosh Kumar Srivastava, Lucknow, IN;
Ashok Kumar Agrawal, Lucknow, IN;
Subhash Chandra Singh, Lucknow, IN;
Vinay Kumar Khanna, Lucknow, IN;
Janardan Singh, Lucknow, IN;
Chandeshwar Nath, Lucknow, IN;
Madan Mohan Gupta, Lucknow, IN;
Shikha Gupta, Lucknow, IN;
Ram Kishor Verma, Lucknow, IN;
Anirban Pal, Lucknow, IN;
Dnyaneshwar Umrao Bawankule, Lucknow, IN;
Dharmendra Saikia, Lucknow, IN;
Anil Kumar Gupta, Lucknow, IN;
Anupam Maurya, Lucknow, IN;
Suman Preet Singh Khanuja, Lucknow, IN;
Council of Scientific & Industrial Research, New Delhi, IN;
Abstract
The present invention relates to bioactive extracts its fractions and isolation of compound from. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D, Cholinergic (muscarinic) and Serotonergic (5HT) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and α-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions ofand in the isolated compounds α-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS).