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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9018224 B1

PDFFull Text
Date of Patent:
Apr. 28, 2015

Filed:

Nov. 09, 2012

Substituted cyclopropyl compounds useful as gpr119 agonists

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Scott Edmondson, Clark, NJ (US);

Zhiyong Hu, Livingston, NJ (US);

Ping Liu, Westfield, NJ (US);

Gregori J. Morriello, Randolph, NJ (US);

Jason W. Szewczyk, Collegeville, PA (US);

Bowei Wang, Westfield, NJ (US);

Liping Wang, Cranbury, NJ (US);

Harold B. Wood, Westfield, NJ (US);

Cheng Zhu, Edison, NJ (US);

Yuping Zhu, Basking Ridge, NJ (US);

Zhiqiang Guo, Morganville, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Anna L. Cocuzzo

Catherine D. Fitch

Primary Examiner:

Alexander R Pagano

Int. Cl.
CPC ...
A01N 43/54 (2006.01); A61K 31/505 (2006.01); C07D 513/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/04 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01); C07D 498/04 (2006.01); C07D 239/42 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 401/04 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01); C07D 239/42 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01);
Abstract

Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.

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