The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2015
Filed:
Jan. 24, 2014
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Alexander Pasternak, Princeton, NJ (US);
Yuping Zhu, Basking Ridge, NJ (US);
Aurash Shahripour, Iselin, NJ (US);
Haifeng Tang, Metuchen, NJ (US);
Lihu Yang, Edison, NJ (US);
Shawn P. Walsh, Bridgewater, NJ (US);
Nardos H. Teumelsan, Rahway, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.