The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 28, 2015

Filed:

Sep. 25, 2006
Applicants:

William L. Jorgensen, Deep River, CT (US);

Juliana Ruiz-caro, Rainbach, AT;

Andrew D. Hamilton, Guilford, CT (US);

Inventors:

William L. Jorgensen, Deep River, CT (US);

Juliana Ruiz-Caro, Rainbach, AT;

Andrew D. Hamilton, Guilford, CT (US);

Assignee:

Yale University, New Haven, CT (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/513 (2006.01); A61K 31/495 (2006.01); A61K 31/519 (2006.01); A61K 31/44 (2006.01); A61K 31/425 (2006.01); C07D 251/42 (2006.01); C07D 491/00 (2006.01); C07D 495/00 (2006.01); C07D 471/04 (2006.01); C07D 277/42 (2006.01); C07D 213/74 (2006.01); C07D 217/22 (2006.01); C07D 239/42 (2006.01); C07D 239/47 (2006.01); C07D 239/48 (2006.01); C07D 239/94 (2006.01); C07D 277/56 (2006.01); C07D 487/04 (2006.01); C07D 493/04 (2006.01);
U.S. Cl.
CPC ...
C07D 277/42 (2013.01); C07D 213/74 (2013.01); C07D 217/22 (2013.01); C07D 239/42 (2013.01); C07D 239/47 (2013.01); C07D 239/48 (2013.01); C07D 239/94 (2013.01); C07D 251/42 (2013.01); C07D 277/56 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 493/04 (2013.01);
Abstract

The present invention relates to compounds according to the formula I: Where Ris H or an optionally OH-substituted C-Calkyl; Ris OR, an optionally substituted Ccarbocyclic group which may be saturated or unsaturated (including aromatic) or an optionally substituted heterocyclic group; Ris an optionally substituted C-Chydrocarbyl group or an optionally substituted heterocyclic group; R, Rand Rare each independently H, an optionally substituted C-Calkyl group (preferably CH, CHCHor CF), halogen (preferably F, Cl, Br), OR, CN, NO, a C-Cthioether, a C-Cthioester group, an optionally substituted COR group, an optionally substituted COR group or an optionally substituted OCOR group (preferably Ris H); R is H or an optionally substituted C-Calkyl group; RHET is an optionally substituted heterocyclic group; and pharmaceutically acceptable salts, solvates or polymorphs thereof.


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