The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2015
Filed:
Mar. 15, 2012
Thomas Müller-späth, Zürich, CH;
Lars Aumann, Zürich, CH;
Guido Ströhlein, Zürich, CH;
Michael Bavand, Lenzburg, CH;
Thomas Müller-Späth, Zürich, CH;
Lars Aumann, Zürich, CH;
Guido Ströhlein, Zürich, CH;
Michael Bavand, Lenzburg, CH;
ChromaCon AG, Zurich, CH;
Abstract
The document pertains to a method for the purification of a ternary mixture of dimeric antibodies of the type AA, AB, BB, characterized in that for the separation of the three components and in particular for the isolation of the multi-specific fraction AB multicolumn counter current solvent gradient purification chromatography with a stationary phase load of more than 1 mg antibody mixture per milliliter stationary phase is used. It furthermore relates to a method for the identification of in particular bispecific antibody systems, which are particularly suitable for the application of such a purification method.