The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2015
Filed:
May. 12, 2006
Susan L. Lindquist, Chestnut Hill, MA (US);
Aaron D. Gitler, Philadelphia, PA (US);
Anil Cashikar, Martinez, GA (US);
Susan L. Lindquist, Chestnut Hill, MA (US);
Aaron D. Gitler, Philadelphia, PA (US);
Anil Cashikar, Martinez, GA (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Abstract
Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.